sábado, 30 de agosto de 2014

THE TREATMENT OF CANCER WITH CHINESE MEDICINE

I am presenting here the Chinese medicine view of cancer with patterns, treatment  principle, herbs and herbal formulae. Very many of our patient have or have had cancer (or will have cancer) and, for this reason, I think it is extremely important to understand cancer from the point of view of Chinese medicine, even if we do not actually treat it.  Moreover, even if we do not treat cancer itself, we can do our patients who have survived cancer a great service if we can develop treatment strategies to prevent recurrence. 

All Chinese books try to “prove” that the concept of cancer was already in the Nei Jing and other later books.  The truth is that, while the ancient books have a fairly comprehensive theory of tumours, there was no concept of malignancy or of differentiation between benign and malignant tumours.  

There are, however, some passages that clearly indicate that, when treating tumours, the ancient doctors were well aware when a condition indicated a poor prognosis.  

For example, a text of the Song dynasty says when describing ru yan, i.e. a hard breast lump: “If it has not broken, the patient can be saved.  If it has broken, treatment is difficult. On palpation, it is as hard as a rock, hence the name [ru yan, breast rock].  If treated too late, it will ulcerate and spread to the Zang organs and is fatal.”

Please note that some of the descriptions of tumours in the ancient books (as the one above) actually describe secondary infections from cancer rather than the cancer pathology itself. The tongue below shows one such case.  We will very seldom see such infections because women will seek Western treatment much earlier than ancient Chinese women would have done.  




Moreover, the Chinese medicine theory of cancer refers only to masses and therefore 
does not envisage cancer without masses such as blood tumours (leukemia, myeloma).  

In spite of the fact that Chinese medicine had no concept of malignancy, I believe it has a lot to offer in four areas:

1) Treat the cancer itself without Western treatment
2) Treat the cancer in integration with Western treatment
3) Treat the side-effects of chemotherapy and radiotherapy
4) Prevent recurrence after Western treatment.

Chapter 55 of the Nan Jing introduces the term Ji Ju indicating "masses".

How to distinguish between Ji [积] and Ju [聚]?  Ji [masses] are Yin and Ju [masses] are Yang. Yin is deep and hidden; Yang is superficial and moves. When Qi accumulates it gives rise to Ji [masses]; when Qi gathers it gives rise to Ju [masses].  Ji [masses] originate from the 5 Zang; Ju [masses] originate from the 6 Fu.  Ji [masses] are made of Yin Qi and have a fixed location and pain, and have boundaries above and below, and edges to the right and left [i.e. they have clearly defined borders].  Ju [masses] are made of Yang Qi and seem to start from nowhere, without a boundary above and below and with a moving pain."

Abdominal masses are called Ji Ju [积 聚].  Ji indicates actual abdominal masses which are immovable; if there is an associated pain, its location is fixed.  These masses are due to stasis of Blood.  I call them "Blood masses".  

Ju indicates abdominal masses which come and go, do not have a fixed location and are movable; if there is an associated pain, it too comes and goes and changes location.  Such masses are due to stagnation of Qi.  I call them "Qi masses". 

Actual abdominal lumps therefore pertain to the category of abdominal masses and specifically Ji masses, and are due to Blood stasis.  I call them “Blood masses”.    

Another name for abdominal masses was Zheng Jia [癥瘕],  Zheng being equivalent to Ji, i.e. actual, fixed masses and Jia to Ju, i.e. non-substantial masses from stagnation of Qi.  

Zheng Jia is normally used in referring to abdominal masses that generally occur only in women; but they do occur in men as well, though rarely.  

The “Su Wen” in chapter 60 says: “Diseases of the Ren Mai...in women are masses below the waist."   

In this context, the “Su Wen” uses the term Jia-Ju, i.e. non-substantial masses from Qi stagnation.

The "Prescriptions of the Golden Cabinet“ [Jin Gui Yao Lue] by Zhang Zhong Jing 
says: "Ji masses arise from the Yin organs and they cannot be moved;  Ju masses arise from the Yang organs, they come and go, the pain has no fixed location, and they are easier to treat."

The "General Treatise on the Aetiology and Symptoms of Diseases" (AD 610) says: "Abdominal masses are due to cold and heat not being regulated [i.e. exposure to extremes of  weather], irregular diet and stagnation of the Qi of the Yin organs.  If they do not move they are called Zheng; if they are movable they are called Jia.  "Jia" implies the meaning of "false": this is because these masses can come and go and are not actual masses."


Terminology

Liu 瘤 tumour

Zhong Liu 肿 瘤 tumour, cancer

Shi Yong 石 痈 Stone Carbuncle, a condition described in the old books that could correspond to some cancers

Ai 癌 modern word for cancer

Yan 岩 “rock”, a description of some tumours that are hard and that could correspond to cancer

Ji Ju (Nan Jing, 55) 积 聚 masses, described in chapter 55 of the Nan Jing

Zheng Jia 癥 瘕 gynaecological abdominal masses 


Aetiology and pathology of cancer




Patterns

The main patterns appearing in cancer are Blood stasis, Phlegm and Toxic Heat.

Blood stasis: abdominal masses, cancer of colon, carcinoma of breast, ovarian cancer.

Phlegm: brain tumour, breast carcinoma, lymphoma.

Toxic Heat: cancers that spread rapidly.

Dampness: skin cancer (only cancer characterized by Dampness).

NOTE: many types of cancer have both Blood stasis and Phlegm.  Example: breast, colon, lung, prostate.

That is why the combination of Blood stasis and Phlegm is particularly serious and, in a patient without cancer, it should be actively treated.  

The tongue is an important factor to diagnose the combination of Blood stasis and Phlegm.

Blood stasis: purple, stiff.
Phlegm: swollen, sticky coating.


Purple, swollen


Purple, swollen, sticky coating


Purple, swollen


Purple, swollen

TREATMENT STRATEGIES

a) DIFFERENCE BETWEEN CANCER AND OTHER DISEASES: UNDERLYING QI XU

b) IDENTIFICATION OF PATTERNS IS BASIS OF TREATMENT BUT NOT ENOUGH

c) DIFFERENT APPROACH TO TREATMENT

d) INTEGRATE CHINESE DIAGNOSIS WITH WESTERN DIAGNOSIS

e) INTEGRATE CHINESE WITH WESTERN TREATMENT

f) NOT ALL CANCERS ARE THE SAME CHINESE DISEASE

a) UNDERLYING QI XU

Cancer is seen differently than any other disease as we can always assume there is an underlying Qi Xu.  I mean “Qi” in a general sense of Zheng Qi, therefore including Qi, Yang, Blood or Yin Xu. 

In other diseases, we never assume that there is a Qi Xu.  We can assume there is a situation of Qi Xu in cancer as this develops over a long period of time from accumulation of Qi, Blood, Phlegm which cannot occur without an underlying Qi Xu. 

Another important difference is that in cancer, the disease itself consumes Qi.

Please note that, just because there is Qi Xu, it does not mean that we tonify Zheng Qi in all cases of cancer. 

b) IDENTIFICATION OF PATTERNS IS BASIS OF TREATMENT BUT NOT ENOUGH

We cannot treat cancer without a pattern differentiation as we do in any other disease.  However, pattern identification alone is not enough in cancer.

One reason is that we can assume there is always Zheng Qi Xu while we should never make such assumptions in other diseases.

Another difference is that the choice of herbs is guided not only by pattern differentiation but also by modern research on anti-cancer effect.

Another factor is surgery for cancer.  After surgery for cancer, we cannot entirely diagnose from a Chinese perspective.  For example, in breast lumps (benign or malignant) we diagnose from palpation (Phlegm or Blood stasis): this is obviously no longer possible after surgery.

c) DIFFERENT APPROACH TO TREATMENT

The first difference is that in cancer we can assume that there is a deficiency of Zheng Qi and therefore we must use some tonics in every case. 

The second important difference is that the choice of herbs is guided also by modern research.  

The third important difference is in the treatment principle according to stage of disease.  In other diseases, generally in the beginning stage one expels pathogenic factors and in the late stage one tonifies.  

It is the opposite in cancer, i.e. in the beginning stage one primarily tonifies and in the late stage one primarily expels pathogenic factors.

The emphasis is in the word “primarily” as one always adopts both approaches in each stage. 

An example of another disease might be MS.  In the beginning stages, there is invasion of Dampness and the treatment principle is therefore to eliminate Dampness.  If the disease progresses, there will be deficiency of Stomach and Spleen and, later, deficiency of Yin of Liver and Kidneys.  In late stages therefore one must tonify Zheng Qi.

In cancer, the beginning stage is characterized by deficiency of Zheng Qi (without which there would not be cancer) and one should therefore primarily tonify to prevent the cancer from growing and spreading.  In late stages, the pathology of cancer is characterized by strong pathogenic factors, i.e. Blood stasis, Phlegm and Toxic Heat. 

I repeat, the stress is on the word “primarily” as we always adopt both treatments, i.e. tonify Zheng Qi and expel pathogenic factors but in different proportions according to stage. 

                                     BEGINNING STAGE        LATE STAGE
OTHER DISEASES Expel pathogenic factor     Tonify Zheng Qi

CANCER                      Tonify Zheng Qi                  Expel pathogenic factors

d) INTEGRATE CHINESE DIAGNOSIS WITH WESTERN DIAGNOSIS

This is of course very obvious.  We should never rely on palpation and a Chinese diagnosis in breast lumps, for example.  The same applies to any other cancer.  

Another example would be that of prostate cancer.  If a man has urinary retention, we should never treat that without a prostate biopsy to ascertain whether there is carcinoma.  

Western diagnosis also presents us with new opportunities that ancient Chinese doctors would not have had.  For example, when cervical dysplasia is diagnosed with a Pap smear test, we can treat that (usually very successfully) before it may turn into cervical cancer. 

e) INTEGRATE CHINESE WITH WESTERN TREATMENT


In most cases, we need to integrate our treatment with Western treatment, i.e. chemotherapy, radiotherapy and surgery.

The only times I used only Chinese treatment was when the patient themselves were strongly against Western treatment. 

During chemotherapy and radiotherapy, our attention is not directed at treating the cancer but only at supporting Zheng Qi during such treatments.

After chemotherapy and radiotherapy, we should make a clear diagnosis as to whether there are still strong pathogenic factors or not in order to decide whether we should primarily tonify or primarily expel pathogenic factors.  

f) NOT ALL CANCERS ARE THE SAME CHINESE DISEASE

Besides doing a pattern identification [Bian Zheng] we must also identify the disease [Bian Bing] as cancer manifests with a wide variety of Chinese “diseases”.  Thus we must be familiar with the aetiology and pathology of the Chinese disease with which cancer manifests. 

Thus, although we must treat cancer differently than other diseases, we must also master the aetiology and pathology of the Chinese disease corresponding to the particular type of cancer we are treating.  That will give us many indications as to treatment, choice of prescriptions and useful herbs. 

The following Tables illustrate the correspondence between Chinese diseases and types of cancer. 

ZANG TUMOURS

LOCATION CHINESE PINYIN     MEANING                       POSSIBLE CANCER
Liver              干 积            Gan Ji         Liver accumulation         Liver carcinoma
Spleen            脾 积            Pi Ji            Spleen accumulation       Carcinoma of pancreas
Lung              肺 积             Fei Ji          Lung accumulation          Lung cancer
Kidney           肾岩             Shen Yan   Kidney cancer (“rock”)   Kidney cancer


FU TUMOURS

CHINESE PINYIN            MEANING                     POSSIBLE CANCER
胃 反         Wei Fan             Stomach rebellious     Liver carcinoma
噎 膈         Ye Ge                 Dysphagia                     Carcinoma of pancreas
脑 沙         Nao Sha             Brain “Sand”                 Lung cancer
鎖 肛 痔    Suo Gang Zhi    Haemorrhoids               Kidney cancer
积聚          Ji Ju Masses      Abdominal masses       Gynaecological masses
腸 痰         Chang Tan         Intestines Phlegm        Colon cancer (ovarian cancer)

CHANNEL TUMOURS

CHINESE PINYIN       MEANING                         POSSIBLE CANCER
瘰 疬         Luo Li          Scrofula                                 Lymphoma
痰 結         Tan Jie         Phlegm accumulation          Lymphoma (lipoma)
石 疔         Shi Ding        Stone Boil                             Skin cancer
肉 痳         Rou Lin        Lumps under skin                Lymphoma (lipoma)
石 廮         Shi Ying        Stone Goitre                         Carcinoma of thyroid
妒 乳        Du Ru           “Jealous Breast”                    Breast carcinoma
失 榮        Shi Rong        Loss of Lustre (neck lump) Lymphoma, sarcoma
石 阻        Shi Zu            Stone Obstruction                 Skin cancer
恶 核        E He               Obstinate Nodule                 Lymphoma



OTHER TUMOURS
CHINESE PINYIN     MEANING                  POSSIBLE CANCER
勞 瘵         Lao Zhai     Consumption Disease   Late stage of any cancer
虛 勞         Xu Lao       Exhaustion                    Late stage of any cancer
熱 癆         Re Lao       Heat Exhaustion            Leukemia
骨 癆         Gu Lao       Bone Consumption       Bone cancer
喉 痹         Hou Bi        Throat Bi                      Throat cancer
膈 肿         Ge Zhong    Diaphragm swelling Carcinoma oesophagus
石 瘕         Shi Jia         Stone Masses               Carcinoma uterus

APPROACH TO TREATMENT AFTER WESTERN TREATMENT 

It is important to have a clear idea how to approach the treatment of a patient after he or she has had Western treatment (chemotherapy, radiotherapy or surgery) as we will see very many patients after such treatment.  

The approach depends on the type of treatment they had.  Basically, one must decide whether we should primarily tonify the Zheng Qi with the aim of preventing recurrence of the cancer or whether we should still primarily expel pathogenic factors in spite of the Western treatment received.  

For example, if a woman had breast cancer from Phlegm and she had a mastectomy, does it make sense to still resolve Phlegm?  In some cases, yes.  I choose the treatment principle a lot according to tongue and pulse.  If the tongue and pulse show a Full condition, then I primarily expel pathogenic factors, but always with the addition of herbs to tonify Zheng Qi and support the immune system.

Tongues indicating a primarily Full conditions: swollen, thick coating, purple, stiff.

Tongues indicating a primarily Empty condition: not so purple, not swollen, thin coating or no coating.  


Purple, thick coating

Purple, swollen

Red, thick-dry coating

A pulse indicating a Full condition is Full, Slippery or Wiry and possibly Rapid.

A pulse indicating an Empty condition is Weak, Fine or Choppy. 

Thus, if the tongue and pulse indicate a primarily Full condition, I treat the patient as if they still had the cancer.

How to choose the herbal formula?  First of all, I refer to the Chinese disease corresponding to that type of cancer in order to see if there is a Chinese formula that can be adapted to the patient.  

Apart from the Chinese disease, the formula must also be based on the pattern: therefore a good pattern identification is essential.

I then modify the formula is three ways:

1) Make additions or subtractions according to the patient’s condition in the same way as I would for any disease. 

2) Add 2-3 herbs that have a proven anti-cancer effect according to modern research.  Is there herbs also treat the presenting pattern, even better.  For example, Huang Yao Zi has an anti-cancer effect and resolves Phlegm: we would therefore choose that herb if there is Phlegm.

3) Add 2-3 herbs that tonify Zheng Qi and stimulate the immune system.  If they also have an anti-cancer effect, all the better.  


APPROACH TO TREATMENT DURING CHEMOTHERAPY AND RADIOTHERAPY TREATMENT

During treatment with chemotherapy and radiotherapy, I do not treat the patterns, but only tonify Zheng Qi in order to support the organism during this treatment.

For chemotherapy, I use the Three Treasures remedy Chemo-Support and for radiotherapy Radio-Support.  The treatment principle of Chemo-Support is to tonify Zheng Qi, resolve Dampness and clear Heat. 

For radiotherapy, I use the Three Treasures remedy Radio-Support.  The treatment principle of Radio-Support is to nourish, cool and invigorate Blood. 

More information on Chemo-Support can be found on: 
http://www.three-treasures.com/newsletters/summer05.html

More information on Radio-Support can be found on: 
http://www.three-treasures.com/newsletters/winter00.html

More information on chemotherapy and antioxidants can be found on:
http://www.three-treasures.com/newsletters/spring10.html


Please note that the effects of radiotherapy can be long-lasting and I therefore advocate using Radio-Support for at least 9 months after the end of the treatment.